Eptifibatide

Brand: Integrilin (US/EU) / Eptifiban (IN) / Eptif (BD)

Antiplatelet GP IIb/IIIa inhibitor (IV, cyclic peptide)

Chemistry

Molecular Formula	C35H49N11O9S2
PubChem	CID: 60776 Open in PubChem

Structure

Half-life	2.5 hours
Tmax	0 h
Protein Binding	25 %
Volume of Distribution	0.2 L/kg (approx)
Clearance Route	renal
Active Metabolites	no
Notes	Short plasma half-life but infusion during PCI maintains effect; dose reduction required in renal impairment.

Severity: Moderate

Adverse Effects:
Bleeding, thrombocytopenia, hypotension, back pain

Contraindications:
Active bleeding, recent stroke, severe renal impairment without dose adjustment

Precautions:
Monitor platelets; adjust dose for renal function; discontinue before invasive procedures