Valsartan
Brand: Diovan (US/EU) / Valzaar (IN) / Valsar (BD)
Antihypertensive
Angiotensin II receptor blocker (ARB)
Pharmacokinetics
| Half-life | 9 hours |
| Tmax | 2 h |
| Bioavailability | 25 % (approx) |
| Protein Binding | 95 % |
| Volume of Distribution | 0.2 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | no |
| Notes | Not a prodrug; highly protein bound; used in HF and post-MI due to mortality benefit. |
⚠️ Safety & Warnings
Severity: Moderate
Adverse Effects:
Dizziness, hyperkalemia, hypotension; rare angioedema
Contraindications:
Pregnancy, bilateral renal artery stenosis
Precautions:
Monitor potassium and renal function; preferred ARB in heart failure and post-MI