Imipramine
Brand: Tofranil (US/EU) / Depsonil (IN) / Imipra (BD)
Antidepressant
TCA (Tricyclic antidepressant)
Pharmacokinetics
| Half-life | 20 hours |
| Tmax | 4 h |
| Bioavailability | 50 % (approx) |
| Protein Binding | 90 % |
| Volume of Distribution | 15 L/kg (approx) |
| Clearance Route | hepatic |
| Active Metabolites | yes |
| Notes | Active metabolite: desipramine. Cardiotoxicity risk high in overdose. |
⚠️ Safety & Warnings
Severity: Severe
Adverse Effects:
Anticholinergic effects, sedation, orthostatic hypotension, arrhythmias
Contraindications:
Severe cardiac disease, recent MI, MAOI therapy
Precautions:
Avoid in elderly; caution in seizure disorder; ECG monitoring in high-risk patients.