Anticancer Class
Showing 6 drugs
starting with: A
Abemaciclib
Brand: Verzenio
Class: Anticancer
Subclass: CDK4/6 inhibitor
PK:
t½ 18 hours | Clearance: hepatic
Max Dose: 300 day
Max Dose: 300 day
severe
AE: Diarrhoea, neutropenia, fatigue
AE: Diarrhoea, neutropenia, fatigue
Ado-Trastuzumab Emtansine
Brand: Kadcyla (global) / T-DM1 (IN/BD)
Class: Anticancer
Subclass: HER2 ADC (trastuzumab + DM1)
PK:
t½ 96 hours | Clearance: hepatic
Max Dose: 10 day
Max Dose: 10 day
severe
AE: Hepatotoxicity, thrombocytopenia, peripheral neuropathy, pneumonitis
AE: Hepatotoxicity, thrombocytopenia, peripheral neuropathy, pneumonitis
Afatinib
Brand: Giotrif (global) / Afatinib (IN/BD)
Class: Anticancer
Subclass: EGFR/HER2 irreversible TKI
PK:
t½ 37 hours | Clearance: renal
Max Dose: 50 day
Max Dose: 50 day
moderate
AE: Rash, diarrhoea, stomatitis
AE: Rash, diarrhoea, stomatitis
Alectinib
Brand: Alecensa (global)
Class: Anticancer
Subclass: ALK inhibitor (2nd generation)
PK:
t½ 32.5 hours | Clearance: hepatic
Max Dose: 1200 day
Max Dose: 1200 day
moderate
AE: Constipation, myalgia, elevated CPK, hepatotoxicity
AE: Constipation, myalgia, elevated CPK, hepatotoxicity
Atezolizumab
Brand: Tecentriq (global) / Atezolizumab (IN/BD)
Class: Anticancer
Subclass: PD-L1 Immune Checkpoint Inhibitor
PK:
t½ 648 hours | Clearance: hepatic
Max Dose: 1200 day
Max Dose: 1200 day
life-threatening
AE: Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies
AE: Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies
Avelumab
Brand: Bavencio (global) / Avelumab (IN/BD)
Class: Anticancer
Subclass: PD-L1 Immune Checkpoint Inhibitor
PK:
t½ 156 hours | Clearance: other
Max Dose: 10 day
Max Dose: 10 day
life-threatening
AE: Immune pneumonitis, hepatitis, colitis; infusion reactions common
AE: Immune pneumonitis, hepatitis, colitis; infusion reactions common