Anticancer Class
Showing 9 drugs
starting with: C
Capecitabine
Brand: Xeloda (global)
Class: Anticancer
Subclass: Antimetabolite (oral prodrug of 5-FU)
PK:
t½ 0.75 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
severe
AE: Diarrhea, hand-foot syndrome, mucositis, fatigue, cardiotoxicity (rare)
AE: Diarrhea, hand-foot syndrome, mucositis, fatigue, cardiotoxicity (rare)
Capmatinib
Brand: Tabrecta (global)
Class: Anticancer
Subclass: MET inhibitor
PK:
t½ 6.5 hours | Clearance: hepatic
Max Dose: 800 day
Max Dose: 800 day
moderate
AE: Peripheral edema, nausea, fatigue, photosensitivity, ILD/pneumonitis
AE: Peripheral edema, nausea, fatigue, photosensitivity, ILD/pneumonitis
Carboplatin
Brand: Paraplatin (global)
Class: Anticancer
Subclass: Platinum compound (DNA crosslinker)
PK:
t½ 5 hours | Clearance: renal
Max Dose: not added
Max Dose: not added
moderate
AE: Myelosuppression (especially thrombocytopenia), nausea/vomiting, less nephrotoxicity than cisplatin
AE: Myelosuppression (especially thrombocytopenia), nausea/vomiting, less nephrotoxicity than cisplatin
Cemiplimab
Brand: Libtayo (global)
Class: Anticancer
Subclass: PD-1 monoclonal antibody
PK:
t½ 19 days | Clearance: hepatic
Max Dose: not added
Max Dose: not added
severe
AE: Immune mediated pneumonitis, colitis, hepatitis, endocrinopathies
AE: Immune mediated pneumonitis, colitis, hepatitis, endocrinopathies
Ceritinib
Brand: Zykadia (global)
Class: Anticancer
Subclass: ALK inhibitor (2nd generation)
PK:
t½ 1.7 days | Clearance: hepatic
Max Dose: 450 day
Max Dose: 450 day
moderate
AE: Severe GI toxicity (diarrhea, nausea), hepatotoxicity, QT prolongation, hyperglycemia
AE: Severe GI toxicity (diarrhea, nausea), hepatotoxicity, QT prolongation, hyperglycemia
Cisplatin
Brand: Platinol (global)
Class: Anticancer
Subclass: Platinum compound (DNA crosslinker)
PK:
t½ 70 hours | Clearance: renal
Max Dose: not added
Max Dose: not added
severe
AE: Nephrotoxicity, ototoxicity, peripheral neuropathy, severe nausea/vomiting
AE: Nephrotoxicity, ototoxicity, peripheral neuropathy, severe nausea/vomiting
Cobimetinib
Brand: Cotellic (global)
Class: Anticancer
Subclass: MEK inhibitor
PK:
t½ 44 hours | Clearance: hepatic
Max Dose: 60 day
Max Dose: 60 day
severe
AE: Rhabdomyolysis, CPK elevation, serous retinopathy, diarrhea
AE: Rhabdomyolysis, CPK elevation, serous retinopathy, diarrhea
Crizotinib
Brand: Xalkori (global)
Class: Anticancer
Subclass: ALK / ROS1 inhibitor (1st gen)
PK:
t½ 42 hours | Clearance: hepatic
Max Dose: 500 day
Max Dose: 500 day
moderate
AE: Visual disturbances (common), QT prolongation, hepatotoxicity, GI upset, bradycardia
AE: Visual disturbances (common), QT prolongation, hepatotoxicity, GI upset, bradycardia
Cytarabine
Brand: DepoCyt (liposomal) / Cytarabine generic
Class: Anticancer
Subclass: Antimetabolite (pyrimidine analogue)
PK:
t½ 1.5 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
severe
AE: Myelosuppression, cerebellar toxicity (high dose), conjunctivitis
AE: Myelosuppression, cerebellar toxicity (high dose), conjunctivitis