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Anticancer Class

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Showing 4 drugs starting with: L

Lapatinib

Brand: Tykerb (global)
Class: Anticancer
Subclass: HER2 / EGFR dual TKI
PK: t½ 14 hours | Clearance: hepatic
Max Dose: 1250 day
moderate
AE: Diarrhoea, hepatotoxicity, rash, cardiotoxicity

Larotrectinib

Brand: Vitrakvi (global)
Class: Anticancer
Subclass: NTRK selective inhibitor
PK: t½ 3 hours | Clearance: hepatic
Max Dose: 200 day
moderate
AE: Dizziness, fatigue, nausea, hepatotoxicity

Lenalidomide

Brand: Revlimid (global)
Class: Anticancer
Subclass: Immunomodulatory agent (IMiD)
PK: t½ 3 hours | Clearance: renal
Max Dose: not added
severe
AE: Myelosuppression, thrombosis, fatigue, rash

Lorlatinib

Brand: Lorbrena (global)
Class: Anticancer
Subclass: ALK inhibitor (3rd gen)
PK: t½ 24 hours | Clearance: hepatic
Max Dose: 100 day
moderate
AE: Cognitive/mood changes, hyperlipidemia, neuropathy, edema, weight gain