Antimalarial Class
Showing 3 drugs
starting with: A
Artemether-Lumefantrine
Brand: Coartem / Artefan / generic AL
Class: Antimalarial
Subclass: ACT (artemisinin combination therapy)
PK:
t½ 3 days | Clearance: hepatic
Max Dose: not added
Max Dose: not added
moderate
AE: Headache, dizziness, GI upset, palpitations; mild transient ECG changes (QT prolongation) possible.
AE: Headache, dizziness, GI upset, palpitations; mild transient ECG changes (QT prolongation) possible.
Artesunate
Brand: Artesunate (IN/BD generic)
Class: Antimalarial
Subclass: Artemisinin derivative
PK:
t½ 1 hours | Clearance: hepatic
Max Dose: 600 day
Max Dose: 600 day
moderate
AE: Generally well tolerated; transient neutropenia, mild liver enzyme elevation, rare delayed hemolysis after parenteral therapy.
AE: Generally well tolerated; transient neutropenia, mild liver enzyme elevation, rare delayed hemolysis after parenteral therapy.
Atovaquone–Proguanil
Brand: Malarone
Class: Antimalarial
Subclass: Mitochondrial ETC inhibitor + DHFR inhibitor
PK:
t½ 48 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
moderate
AE: Abdominal pain, nausea, vomiting, headache, elevated liver enzymes, mouth ulcers (due to proguanil). Rare: hallucinations.
AE: Abdominal pain, nausea, vomiting, headache, elevated liver enzymes, mouth ulcers (due to proguanil). Rare: hallucinations.