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Analgesic Class

Tapentadol

Brand: Nucynta / Palexia
Subclass: Opioid analgesic (µ-opioid agonist + norepinephrine reuptake inhibitor)
PK: t½ 4 hours | Clearance: hepatic
Max Dose: 700 day
severe
AE: Nausea, vomiting, dizziness, somnolence, constipation, headache, respiratory depression

Tramadol

Brand: Ultram (US) / Tramazac (IN) / Tramafen (BD)
Subclass: Opioid analgesic (atypical)
PK: t½ 6 hours | Clearance: mixed
Max Dose: 400 day
moderate
AE: Nausea, dizziness, somnolence, constipation, seizures, serotonin syndrome, respiratory depression