Neurological Class
Apomorphine
Brand: Apokyn (US) / Apo-Go (EU/IN/BD)
Subclass: Dopamine agonist (non-ergot, rescue injection)
PK:
t½ 0.6 hours | Clearance: hepatic
Max Dose: 6 day
Max Dose: 6 day
moderate
AE: Nausea, vomiting, hypotension, yawning, somnolence, injection-site nodules
AE: Nausea, vomiting, hypotension, yawning, somnolence, injection-site nodules
Citicoline
Brand: CDP-Choline / Citicoline (various)
Subclass: Neuroprotective / cholinergic precursor
PK:
t½ 56 hours | Clearance: renal
Max Dose: 2000 day
Max Dose: 2000 day
mild
AE: Headache, insomnia, nausea, diarrhea; rarely hypotension
AE: Headache, insomnia, nausea, diarrhea; rarely hypotension
Donepezil
Brand: Aricept (US/EU) / Donepezil (IN/BD)
Subclass: Acetylcholinesterase inhibitor (centrally acting)
PK:
t½ 70 hours | Clearance: hepatic
Max Dose: 23 day
Max Dose: 23 day
moderate
AE: Nausea, vomiting, diarrhea, anorexia, weight loss, insomnia, muscle cramps, dizziness, bradycardia, syncope
AE: Nausea, vomiting, diarrhea, anorexia, weight loss, insomnia, muscle cramps, dizziness, bradycardia, syncope
Gabapentin
Brand: Neurontin (US/EU) / Gabastar (IN) / Gabamax (BD)
Subclass: Anti-epileptic / Neuropathic pain
PK:
t½ 6 hours | Clearance: renal
Max Dose: 3600 day
Max Dose: 3600 day
moderate
AE: Sedation, dizziness, peripheral edema
AE: Sedation, dizziness, peripheral edema
Memantine
Brand: Namenda (US/EU) / Ebixa (EU) / Memantine (IN/BD)
Subclass: NMDA receptor antagonist (uncompetitive)
PK:
t½ 70 hours | Clearance: renal
Max Dose: 20 day
Max Dose: 20 day
moderate
AE: Dizziness, headache, confusion, constipation, hypertension, somnolence
AE: Dizziness, headache, confusion, constipation, hypertension, somnolence
Opicapone
Brand: Ongentys (global)
Subclass: COMT inhibitor (peripheral, long-acting)
PK:
t½ 1.5 hours | Clearance: hepatic
Max Dose: 50 day
Max Dose: 50 day
moderate
AE: Dyskinesia, constipation, hypotension, insomnia, elevated LFTs (rare)
AE: Dyskinesia, constipation, hypotension, insomnia, elevated LFTs (rare)
Piracetam
Brand: Nootropil (EU) / Piracetam (IN) / Lucetam (BD)
Subclass: Nootropic (GABA analog, neuronal membrane modulator)
PK:
t½ 5 hours | Clearance: renal
Max Dose: 4800 day
Max Dose: 4800 day
mild
AE: Nervousness, insomnia, agitation, weight gain, GI upset
AE: Nervousness, insomnia, agitation, weight gain, GI upset
Pregabalin
Brand: Lyrica (US/EU) / Pregaba (IN/BD)
Subclass: Neuropathic pain / Central sensitization
PK:
t½ 6 hours | Clearance: renal
Max Dose: 600 day
Max Dose: 600 day
moderate
AE: Dizziness, sedation, euphoria, edema, weight gain
AE: Dizziness, sedation, euphoria, edema, weight gain
Rivastigmine
Brand: Exelon (US/EU) / Rivamer (IN) / Rivastigmine (BD)
Subclass: Cholinesterase inhibitor (AChE + BuChE; pseudo-irreversible)
PK:
t½ 1.5 hours | Clearance: renal
Max Dose: 12 day
Max Dose: 12 day
moderate
AE: Nausea, vomiting, diarrhea, anorexia/weight loss, dizziness, bradycardia, syncope, tremor; patch: application-site reactions
AE: Nausea, vomiting, diarrhea, anorexia/weight loss, dizziness, bradycardia, syncope, tremor; patch: application-site reactions
Rotigotine
Brand: Neupro (global)
Subclass: Dopamine agonist (non-ergot, transdermal patch)
PK:
t½ 5.7 hours | Clearance: hepatic
Max Dose: 16 day
Max Dose: 16 day
moderate
AE: Nausea, dizziness, somnolence, hallucinations, orthostatic hypotension, skin irritation at patch site
AE: Nausea, dizziness, somnolence, hallucinations, orthostatic hypotension, skin irritation at patch site
Safinamide
Brand: Xadago (global)
Subclass: MAO-B inhibitor (reversible, adjunct to levodopa)
PK:
t½ 22 hours | Clearance: hepatic
Max Dose: 100 day
Max Dose: 100 day
moderate
AE: Dyskinesia, insomnia, nausea, hypertension, visual disturbances
AE: Dyskinesia, insomnia, nausea, hypertension, visual disturbances