Anticoagulant Class
Acenocoumarol
Brand: Acitrom / Sintrom / Nicoumalone
Subclass: Vitamin K antagonist
PK:
t½ 10 hours | Clearance: hepatic
Max Dose: 6 day
Max Dose: 6 day
severe
AE: Bleeding (GI/intracranial), skin necrosis (rare in protein C/S deficiency), INR variability, teratogenicity
AE: Bleeding (GI/intracranial), skin necrosis (rare in protein C/S deficiency), INR variability, teratogenicity
Apixaban
Brand: Eliquis (US/EU) / Apigat (IN) / Apixava (BD)
Subclass: NOAC / DOAC (Xa inhibitor)
PK:
t½ 12 hours | Clearance: mixed
Max Dose: 10 day
Max Dose: 10 day
moderate
AE: Bleeding (especially GI), anemia, rare hypersensitivity
AE: Bleeding (especially GI), anemia, rare hypersensitivity
Argatroban
Brand: Argatroban (US/EU) / Argihope (IN) / Argiprax (IN) / Argatro (BD)
Subclass: Direct thrombin inhibitor (parenteral)
PK:
t½ 1 hours | Clearance: hepatic
severe
AE: Bleeding, hypotension, infusion-related reactions, elevated INR during therapy
AE: Bleeding, hypotension, infusion-related reactions, elevated INR during therapy
Bivalirudin
Brand: Angiomax (US/EU) / Bivasave (IN) / Bivacard (IN) / Bivaplex (BD)
Subclass: Direct thrombin inhibitor (parenteral, procedural)
PK:
t½ 0.5 hours | Clearance: mixed
moderate
AE: Bleeding, hypotension, procedural hematoma
AE: Bleeding, hypotension, procedural hematoma
Dabigatran
Brand: Pradaxa (US/EU) / Dabistar (IN) / Drabi (IN/BD)
Subclass: NOAC / DOAC (Thrombin IIa inhibitor)
PK:
t½ 12 hours | Clearance: renal
Max Dose: 300 day
Max Dose: 300 day
moderate
AE: Bleeding (GI > cerebral), dyspepsia, gastritis-like symptoms due to acidic core, rare hypersensitivity
AE: Bleeding (GI > cerebral), dyspepsia, gastritis-like symptoms due to acidic core, rare hypersensitivity
Edoxaban
Brand: Lixiana (EU/JP) / Savaysa (US) / Edoxo (IN) / Edosafe (IN) / Edoxava (BD)
Subclass: NOAC / DOAC (Xa inhibitor)
PK:
t½ 13 hours | Clearance: mixed
Max Dose: 60 day
Max Dose: 60 day
moderate
AE: Bleeding (GI > intracranial), anemia, rare hepatic dysfunction
AE: Bleeding (GI > intracranial), anemia, rare hepatic dysfunction
Enoxaparin
Brand: Clexane / Lovenox
Subclass: Factor Xa–predominant LMWH
PK:
t½ 4.5 hours | Clearance: renal
moderate
AE: Bleeding, injection-site hematoma, rare HIT (much lower risk than UFH)
AE: Bleeding, injection-site hematoma, rare HIT (much lower risk than UFH)
Fondaparinux
Brand: Arixtra (US/EU) / Fondared (IN) / Fondazest (IN) / Fondaplex (BD)
Subclass: Synthetic factor Xa inhibitor (parenteral)
PK:
t½ 17 hours | Clearance: renal
moderate
AE: Bleeding, injection-site hematoma, anemia
AE: Bleeding, injection-site hematoma, anemia
Heparin
Brand: Heparin Sodium / Unfractionated Heparin
Subclass: Unfractionated (IV/SC)
PK:
t½ 1.5 hours | Clearance: other
severe
AE: Bleeding, HIT (heparin-induced thrombocytopenia), osteoporosis with long-term use, hypersensitivity reactions
AE: Bleeding, HIT (heparin-induced thrombocytopenia), osteoporosis with long-term use, hypersensitivity reactions
Rivaroxaban
Brand: Xarelto (US/EU) / Rivaxa (IN) / Rivarox (IN) / Xavira (BD)
Subclass: NOAC / DOAC (Xa inhibitor)
PK:
t½ 9 hours | Clearance: mixed
Max Dose: 20 day
Max Dose: 20 day
moderate
AE: Bleeding (GI > cerebral), dyspepsia, rare hepatic injury
AE: Bleeding (GI > cerebral), dyspepsia, rare hepatic injury
Warfarin
Brand: Coumadin / Marevan / Warfilone
Subclass: Vitamin K epoxide reductase inhibitor
PK:
t½ 36 hours | Clearance: hepatic
Max Dose: 10 day
Max Dose: 10 day
severe
AE: Bleeding (GI, intracranial), skin necrosis (rare, protein C deficiency), purple toe syndrome, teratogenicity (fetal warfarin syndrome)
AE: Bleeding (GI, intracranial), skin necrosis (rare, protein C deficiency), purple toe syndrome, teratogenicity (fetal warfarin syndrome)