NSAID Class
Acetaminophen
Brand: Paracetamol / Tylenol
Subclass: Analgesic / Antipyretic
PK:
t½ 2 hours | Clearance: hepatic
Max Dose: 4000 day
Max Dose: 4000 day
moderate
AE: Nausea, rash, elevated Liver enzymes (ALT/AST) at high dose, rare genetic susceptibility (defective glutathione metabolism → NAPQI accumulation)
AE: Nausea, rash, elevated Liver enzymes (ALT/AST) at high dose, rare genetic susceptibility (defective glutathione metabolism → NAPQI accumulation)
Celecoxib
Brand: Celebrex (global) / Oncoxel, Celcox (IN/BD common brands)
Subclass: Selective COX-2 inhibitor
PK:
t½ 11 hours | Clearance: hepatic
Max Dose: 400 day
Max Dose: 400 day
moderate
AE: Dyspepsia, abdominal pain, edema, hypertension, rare hepatic injury, thrombotic risk
AE: Dyspepsia, abdominal pain, edema, hypertension, rare hepatic injury, thrombotic risk
Diclofenac
Brand: Voveran
Subclass: COX inhibitor / Acetic acid derivative
PK:
t½ 2 hours | Clearance: hepatic
Max Dose: 150 day
Max Dose: 150 day
severe
AE: Gastritis, dyspepsia, edema, elevated liver enzymes, renal function decline RARE: GI bleeding, CV risk (MI/stroke) higher than ibuprofen
AE: Gastritis, dyspepsia, edema, elevated liver enzymes, renal function decline RARE: GI bleeding, CV risk (MI/stroke) higher than ibuprofen
Etoricoxib
Brand: Etorix / Nucoxia / Tauxib (IN/BD generics)
Subclass: Selective COX-2 inhibitor
PK:
t½ 22 hours | Clearance: hepatic
Max Dose: 120 day
Max Dose: 120 day
severe
AE: Dyspepsia, abdominal pain, edema, hypertension, headache, dizziness; increased risk of thrombotic cardiovascular events and, less than non-selective NSAIDs, but still possible…
AE: Dyspepsia, abdominal pain, edema, hypertension, headache, dizziness; increased risk of thrombotic cardiovascular events and, less than non-selective NSAIDs, but still possible…
Ibuprofen
Brand: Advil / Brufen / Motrin
Subclass: Analgesic / Antipyretic /Propionic acid derivative
PK:
t½ 2 hours | Clearance: hepatic
Max Dose: 2400 day
Max Dose: 2400 day
severe
AE: Gastric irritation, dyspepsia, nausea, fluid retention, renal function decline (dose-dependent), **RARE: severe cutaneous reactions including Stevens-Johnson Syndrome (SJS)/TEN**
AE: Gastric irritation, dyspepsia, nausea, fluid retention, renal function decline (dose-dependent), **RARE: severe cutaneous reactions including Stevens-Johnson Syndrome (SJS)/TEN**
Indomethacin
Brand: Indocap, Indomet (IN/BD), Indocin (global)
Subclass: Indole acetic acid derivative
PK:
t½ 4.5 hours | Clearance: hepatic
Max Dose: 200 day
Max Dose: 200 day
moderate
AE: Severe gastric irritation, headache, dizziness, CNS effects, renal impairment, edema, hypertension
AE: Severe gastric irritation, headache, dizziness, CNS effects, renal impairment, edema, hypertension
Ketorolac
Brand: Toradol (global) / Ketanov, Ketorol (IN/BD)
Subclass: Pyrrolo-pyridine carboxylic acid derivative
PK:
t½ 5.3 hours | Clearance: renal
Max Dose: 120 day
Max Dose: 120 day
severe
AE: Severe GI bleeding, renal failure, hypertension, dizziness, injection site pain
AE: Severe GI bleeding, renal failure, hypertension, dizziness, injection site pain
Meloxicam
Brand: Mobic (global) / Melocam, Meloxic (IN/BD)
Subclass: Oxicam derivative (preferential COX-2 inhibitor)
PK:
t½ 20 hours | Clearance: hepatic
Max Dose: 15 day
Max Dose: 15 day
moderate
AE: Dyspepsia, nausea, edema, increased BP, renal impairment; rare SJS/TEN
AE: Dyspepsia, nausea, edema, increased BP, renal impairment; rare SJS/TEN
Naproxen
Brand: Napa-Extend
Subclass: Propionic acid derivative
PK:
t½ 14 hours | Clearance: renal
Max Dose: 1000 day
Max Dose: 1000 day
moderate
AE: GI irritation, edema
AE: GI irritation, edema
Piroxicam
Brand: Feldene (global) / Pirox, Roxicam (IN/BD)
Subclass: Oxicam derivative
PK:
t½ 50 hours | Clearance: hepatic
Max Dose: 20 day
Max Dose: 20 day
severe
AE: Severe gastric ulceration, GI bleed, edema, renal worsening, rash (including SJS/TEN)
AE: Severe gastric ulceration, GI bleed, edema, renal worsening, rash (including SJS/TEN)