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All Analgesic Analgesic Combination Antianginal Antibiotic Anticancer Anticoagulant Anticonvulsant Antidepressant Antidiabetic Antidiarrheal Antihypertensive Antimalarial Antiparasitic Antiparkinson Antiplatelet Antipsychotic Anxiolytic Bronchodilator Cardiovascular Corticosteroid Diuretic Emergency Endocrine Gastrointestinal Immunomodulator Immunosuppressant Minerals Neurological NSAID Oncology – Targeted therapy Psychiatric Sedative/Hypnotic Sympathomimetic Vitamins

Antiparkinson Class

Amantadine

Brand: Symmetrel (US/EU) / Amanex (IN) / Amaflex (BD)
Subclass: NMDA receptor antagonist
PK: t½ 16 hours | Clearance: renal
Max Dose: 300 day
moderate
AE: Livedo reticularis (mottled skin), ankle edema, confusion, dizziness

Carbidopa + Levodopa

Brand: Sinemet (US/EU) / Syndopa (IN) / Tidomet (BD)
Subclass: Dopamine precursor + peripheral decarboxylase inhibitor
PK: t½ 1.5 hours | Clearance: hepatic
Max Dose: 1500 day
moderate
AE: Nausea, dizziness, dyskinesias, hallucinations, orthostatic hypotension

Entacapone

Brand: Comtan (US/EU) / Entacom (IN) / Enta (BD)
Subclass: COMT inhibitor
PK: t½ 1 hours | Clearance: hepatic
Max Dose: 2000 day
moderate
AE: Diarrhea, orange discoloration of urine, dyskinesias (due to ↑ levodopa effect)

Pramipexole

Brand: Mirapex (US/EU) / Pramirol (IN) / Pexola (BD)
Subclass: Dopamine agonist (D2/D3)
PK: t½ 10 hours | Clearance: renal
Max Dose: 4.5 day
moderate
AE: Nausea, orthostatic hypotension, hallucinations, impulse control disorders (gambling, hypersexuality)

Rasagiline

Brand: Azilect (US/EU) / Rasagin (IN) / Rasact (BD)
Subclass: MAO-B inhibitor
PK: t½ 7 hours | Clearance: hepatic
Max Dose: 1 day
moderate
AE: Headache, arthralgia, depression, nausea

Ropinirole

Brand: Requip (US/EU) / Ropin (IN) / Ropinex (BD)
Subclass: Dopamine agonist (D2)
PK: t½ 6 hours | Clearance: hepatic
Max Dose: 24 day
moderate
AE: Nausea, dizziness, hypotension, impulse control disorders

Selegiline

Brand: Eldepryl (US/EU) / Selgin (IN) / Selgine (BD)
Subclass: MAO-B inhibitor
PK: t½ 10 hours | Clearance: hepatic
Max Dose: 10 day
moderate
AE: Insomnia, jitteriness, nausea, hypertension if combined with tyramine-rich foods

Tolcapone

Brand: Tasmar (US/EU) / Tolcap (IN) / Tolcom (BD)
Subclass: COMT inhibitor
PK: t½ 2 hours | Clearance: hepatic
Max Dose: 600 day
severe
AE: Severe hepatotoxicity, diarrhea, dyskinesias, nausea