All Drugs
Showing 33 drugs
starting with: A
Abciximab
Brand: ReoPro (US/EU) / Abcixirel (IN) / Abximab (IN) / Reopro (BD)
Class: Antiplatelet
Subclass: GP IIb/IIIa inhibitor (IV, monoclonal antibody)
PK:
t½ 0.5 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
severe
AE: Bleeding, thrombocytopenia, hypotension, allergic reactions
AE: Bleeding, thrombocytopenia, hypotension, allergic reactions
Abemaciclib
Brand: Verzenio
Class: Anticancer
Subclass: CDK4/6 inhibitor
PK:
t½ 18 hours | Clearance: hepatic
Max Dose: 300 day
Max Dose: 300 day
severe
AE: Diarrhoea, neutropenia, fatigue
AE: Diarrhoea, neutropenia, fatigue
Acenocoumarol
Brand: Acitrom / Sintrom / Nicoumalone
Class: Anticoagulant
Subclass: Vitamin K antagonist
PK:
t½ 10 hours | Clearance: hepatic
Max Dose: 6 day
Max Dose: 6 day
severe
AE: Bleeding (GI/intracranial), skin necrosis (rare in protein C/S deficiency), INR variability, teratogenicity
AE: Bleeding (GI/intracranial), skin necrosis (rare in protein C/S deficiency), INR variability, teratogenicity
Acetaminophen
Brand: Paracetamol / Tylenol
Class: NSAID
Subclass: Analgesic / Antipyretic
PK:
t½ 2 hours | Clearance: hepatic
Max Dose: 4000 day
Max Dose: 4000 day
moderate
AE: Nausea, rash, elevated Liver enzymes (ALT/AST) at high dose, rare genetic susceptibility (defective glutathione metabolism → NAPQI accumulation)
AE: Nausea, rash, elevated Liver enzymes (ALT/AST) at high dose, rare genetic susceptibility (defective glutathione metabolism → NAPQI accumulation)
Adalimumab
Brand: Humira / Exemptia / Hyrimoz
Class: Immunomodulator
Subclass: TNF-alpha inhibitor (human mAb)
PK:
t½ 14 days | Clearance: reticuloendothelial
Max Dose: not added
Max Dose: not added
severe
AE: Injection-site reactions, serious infections (TB, fungal), malignancy risk (lymphoma), hepatitis B reactivation, cytopenias
AE: Injection-site reactions, serious infections (TB, fungal), malignancy risk (lymphoma), hepatitis B reactivation, cytopenias
Adenosine
Brand: Adenocard (US/EU)
Class: Emergency
Subclass: Antiarrhythmic (AV nodal blocker)
PK:
t½ 0.0028 hours | Clearance: other
Max Dose: not added
Max Dose: not added
life-threatening
AE: Transient asystole, flushing, chest discomfort, dyspnea
AE: Transient asystole, flushing, chest discomfort, dyspnea
Ado-Trastuzumab Emtansine
Brand: Kadcyla (global) / T-DM1 (IN/BD)
Class: Anticancer
Subclass: HER2 ADC (trastuzumab + DM1)
PK:
t½ 96 hours | Clearance: hepatic
Max Dose: 10 day
Max Dose: 10 day
severe
AE: Hepatotoxicity, thrombocytopenia, peripheral neuropathy, pneumonitis
AE: Hepatotoxicity, thrombocytopenia, peripheral neuropathy, pneumonitis
Adrenaline
Brand: EpiPen / Adrenaline Injection 1:1000
Class: Sympathomimetic
Subclass: Alpha & Beta adrenergic agonist
PK:
t½ 0.033 hours | Clearance: mixed
Max Dose: not added
Max Dose: not added
severe
AE: Palpitations, tachycardia, hypertension, anxiety, tremor, arrhythmias
AE: Palpitations, tachycardia, hypertension, anxiety, tremor, arrhythmias
Afatinib
Brand: Giotrif (global) / Afatinib (IN/BD)
Class: Anticancer
Subclass: EGFR/HER2 irreversible TKI
PK:
t½ 37 hours | Clearance: renal
Max Dose: 50 day
Max Dose: 50 day
moderate
AE: Rash, diarrhoea, stomatitis
AE: Rash, diarrhoea, stomatitis
Albendazole
Class: Antiparasitic
Subclass: Benzimidazole anthelmintic
PK:
t½ 8 hours | Clearance: hepatic
Max Dose: 800 day
Max Dose: 800 day
moderate
AE: - Elevated liver enzymes - Nausea, abdominal pain - Headache - Rarely bone marrow suppression in long-term use
AE: - Elevated liver enzymes - Nausea, abdominal pain - Headache - Rarely bone marrow suppression in long-term use
Alectinib
Brand: Alecensa (global)
Class: Anticancer
Subclass: ALK inhibitor (2nd generation)
PK:
t½ 32.5 hours | Clearance: hepatic
Max Dose: 1200 day
Max Dose: 1200 day
moderate
AE: Constipation, myalgia, elevated CPK, hepatotoxicity
AE: Constipation, myalgia, elevated CPK, hepatotoxicity
Alprazolam
Brand: Xanax (US/EU) / Restyl (IN) / Alzolam (BD)
Class: Anxiolytic
Subclass: Benzodiazepine anxiolytic (GABA-A positive allosteric modulator)
PK:
t½ 12 hours | Clearance: hepatic
Max Dose: 4 day
Max Dose: 4 day
severe
AE: Sedation, impaired judgment, memory impairment, dependency, withdrawal seizures
AE: Sedation, impaired judgment, memory impairment, dependency, withdrawal seizures
Amantadine
Brand: Symmetrel (US/EU) / Amanex (IN) / Amaflex (BD)
Class: Antiparkinson
Subclass: NMDA receptor antagonist
PK:
t½ 16 hours | Clearance: renal
Max Dose: 300 day
Max Dose: 300 day
moderate
AE: Livedo reticularis (mottled skin), ankle edema, confusion, dizziness
AE: Livedo reticularis (mottled skin), ankle edema, confusion, dizziness
Amiloride
Brand: Midamor (US/EU) / Amifru (IN) / Amilor (BD)
Class: Antihypertensive
Subclass: Potassium-sparing diuretic (Sodium channel blocker)
PK:
t½ 6 hours | Clearance: renal
Max Dose: 20 day
Max Dose: 20 day
moderate
AE: Hyperkalemia, nausea, vomiting, headache, fatigue
AE: Hyperkalemia, nausea, vomiting, headache, fatigue
Amiodarone
Brand: Cordarone/Pacerone (US/EU) / Amiodar (IN/BD)
Class: Emergency
Subclass: Class III antiarrhythmic
PK:
t½ 50 days | Clearance: hepatic
Max Dose: 400 day
Max Dose: 400 day
life-threatening
AE: Pulmonary fibrosis, thyroid dysfunction, hepatotoxicity, corneal deposits, skin discoloration
AE: Pulmonary fibrosis, thyroid dysfunction, hepatotoxicity, corneal deposits, skin discoloration
Amitriptyline
Brand: Elavil (US/EU) / Tryptomer (IN) / Amitone (BD)
Class: Antidepressant
Subclass: TCA (Tricyclic antidepressant)
PK:
t½ 25 hours | Clearance: hepatic
Max Dose: 150 day
Max Dose: 150 day
severe
AE: Anticholinergic effects (dry mouth, constipation, urinary retention), sedation, orthostatic hypotension, arrhythmia risk
AE: Anticholinergic effects (dry mouth, constipation, urinary retention), sedation, orthostatic hypotension, arrhythmia risk
Amlodipine
Brand: Norvasc (US/EU) / Amlopres (IN) / Amlodip (BD)
Class: Antihypertensive
Subclass: Calcium channel blocker (Dihydropyridine)
PK:
t½ 35 hours | Clearance: hepatic
Max Dose: 10 day
Max Dose: 10 day
mild
AE: Pedal edema, flushing, headache, dizziness, palpitations
AE: Pedal edema, flushing, headache, dizziness, palpitations
Amoxicillin
Brand: Amoxil (US/EU) / Mox (IN) / Moxacillin (BD)
Class: Antibiotic
Subclass: Aminopenicillin
PK:
t½ 1 hours | Clearance: renal
Max Dose: 3000 day
Max Dose: 3000 day
moderate
AE: Rash, diarrhea, hypersensitivity
AE: Rash, diarrhea, hypersensitivity
Amoxicillin + Clavulanate
Brand: Augmentin (US/EU/IN) / Amoxyclav (IN) / Clavam (BD)
Class: Antibiotic
Subclass: Aminopenicillin + β-lactamase inhibitor
PK:
t½ 1 hours | Clearance: renal
Max Dose: 3000 day
Max Dose: 3000 day
moderate
AE: Diarrhea, rash, elevated LFTs (more likely than amoxicillin alone), cholestatic jaundice
AE: Diarrhea, rash, elevated LFTs (more likely than amoxicillin alone), cholestatic jaundice
Anastrozole
Brand: Arimidex (global)
Class: Endocrine
Subclass: Aromatase inhibitor
PK:
t½ 50 hours | Clearance: hepatic
Max Dose: 1 day
Max Dose: 1 day
moderate
AE: Bone loss, hot flashes, arthralgias
AE: Bone loss, hot flashes, arthralgias
Apixaban
Brand: Eliquis (US/EU) / Apigat (IN) / Apixava (BD)
Class: Anticoagulant
Subclass: NOAC / DOAC (Xa inhibitor)
PK:
t½ 12 hours | Clearance: mixed
Max Dose: 10 day
Max Dose: 10 day
moderate
AE: Bleeding (especially GI), anemia, rare hypersensitivity
AE: Bleeding (especially GI), anemia, rare hypersensitivity
Apomorphine
Brand: Apokyn (US) / Apo-Go (EU/IN/BD)
Class: Neurological
Subclass: Dopamine agonist (non-ergot, rescue injection)
PK:
t½ 0.6 hours | Clearance: hepatic
Max Dose: 6 day
Max Dose: 6 day
moderate
AE: Nausea, vomiting, hypotension, yawning, somnolence, injection-site nodules
AE: Nausea, vomiting, hypotension, yawning, somnolence, injection-site nodules
Argatroban
Brand: Argatroban (US/EU) / Argihope (IN) / Argiprax (IN) / Argatro (BD)
Class: Anticoagulant
Subclass: Direct thrombin inhibitor (parenteral)
PK:
t½ 1 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
severe
AE: Bleeding, hypotension, infusion-related reactions, elevated INR during therapy
AE: Bleeding, hypotension, infusion-related reactions, elevated INR during therapy
Artemether-Lumefantrine
Brand: Coartem / Artefan / generic AL
Class: Antimalarial
Subclass: ACT (artemisinin combination therapy)
PK:
t½ 3 days | Clearance: hepatic
Max Dose: not added
Max Dose: not added
moderate
AE: Headache, dizziness, GI upset, palpitations; mild transient ECG changes (QT prolongation) possible.
AE: Headache, dizziness, GI upset, palpitations; mild transient ECG changes (QT prolongation) possible.
Artesunate
Brand: Artesunate (IN/BD generic)
Class: Antimalarial
Subclass: Artemisinin derivative
PK:
t½ 1 hours | Clearance: hepatic
Max Dose: 600 day
Max Dose: 600 day
moderate
AE: Generally well tolerated; transient neutropenia, mild liver enzyme elevation, rare delayed hemolysis after parenteral therapy.
AE: Generally well tolerated; transient neutropenia, mild liver enzyme elevation, rare delayed hemolysis after parenteral therapy.
Aspirin
Brand: Ecosprin / Ascard
Class: Antiplatelet
Subclass: COX-1 inhibitor (irreversible)
PK:
t½ 3 hours | Clearance: hepatic
Max Dose: 4000 day
Max Dose: 4000 day
severe
AE: GI irritation, dyspepsia, gastritis, peptic ulcer/bleeding risk, renal impairment (dose-dependent), tinnitus at toxic levels, metabolic acidosis in overdose, Reye's syndrome r…
AE: GI irritation, dyspepsia, gastritis, peptic ulcer/bleeding risk, renal impairment (dose-dependent), tinnitus at toxic levels, metabolic acidosis in overdose, Reye's syndrome r…
Atenolol
Brand: Tenormin
Class: Antihypertensive
Subclass: Beta-blocker
PK:
t½ 6 hours | Clearance: renal
Max Dose: 100 day
Max Dose: 100 day
moderate
AE: Bradycardia, fatigue, cold extremities, depression
AE: Bradycardia, fatigue, cold extremities, depression
Atezolizumab
Brand: Tecentriq (global) / Atezolizumab (IN/BD)
Class: Anticancer
Subclass: PD-L1 Immune Checkpoint Inhibitor
PK:
t½ 648 hours | Clearance: hepatic
Max Dose: 1200 day
Max Dose: 1200 day
life-threatening
AE: Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies
AE: Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies
Atovaquone–Proguanil
Brand: Malarone
Class: Antimalarial
Subclass: Mitochondrial ETC inhibitor + DHFR inhibitor
PK:
t½ 48 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
moderate
AE: Abdominal pain, nausea, vomiting, headache, elevated liver enzymes, mouth ulcers (due to proguanil). Rare: hallucinations.
AE: Abdominal pain, nausea, vomiting, headache, elevated liver enzymes, mouth ulcers (due to proguanil). Rare: hallucinations.
Atropine
Brand: Atropine Sulfate (global)
Class: Emergency
Subclass: Anticholinergic (muscarinic antagonist)
PK:
t½ 2.5 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
moderate
AE: Dry mouth, blurred vision, urinary retention, tachycardia
AE: Dry mouth, blurred vision, urinary retention, tachycardia
Avelumab
Brand: Bavencio (global) / Avelumab (IN/BD)
Class: Anticancer
Subclass: PD-L1 Immune Checkpoint Inhibitor
PK:
t½ 156 hours | Clearance: other
Max Dose: 10 day
Max Dose: 10 day
life-threatening
AE: Immune pneumonitis, hepatitis, colitis; infusion reactions common
AE: Immune pneumonitis, hepatitis, colitis; infusion reactions common
Azathioprine
Brand: Imuran (US/EU) / Azoran (IN) / Azathioprine (BD)
Class: Immunosuppressant
Subclass: Thiopurine antimetabolite
PK:
t½ 5 hours | Clearance: hepatic
Max Dose: 200 day
Max Dose: 200 day
severe
AE: Myelosuppression, hepatotoxicity, pancreatitis, infections
AE: Myelosuppression, hepatotoxicity, pancreatitis, infections
Azithromycin
Brand: Zithromax (US/EU) / Azee (IN) / Azithromycin (BD)
Class: Antibiotic
Subclass: Macrolide
PK:
t½ 68 hours | Clearance: hepatic
Max Dose: 1500 day
Max Dose: 1500 day
moderate
AE: GI upset, QT prolongation, elevated liver enzymes
AE: GI upset, QT prolongation, elevated liver enzymes