All Drugs
Showing 22 drugs
starting with: E
Edoxaban
Brand: Lixiana (EU/JP) / Savaysa (US) / Edoxo (IN) / Edosafe (IN) / Edoxava (BD)
Class: Anticoagulant
Subclass: NOAC / DOAC (Xa inhibitor)
PK:
t½ 13 hours | Clearance: mixed
Max Dose: 60 day
Max Dose: 60 day
moderate
AE: Bleeding (GI > intracranial), anemia, rare hepatic dysfunction
AE: Bleeding (GI > intracranial), anemia, rare hepatic dysfunction
Empagliflozin
Brand: Jardiance (US/EU) / Empa (IN) / Empaglo (BD)
Class: Antidiabetic
Subclass: SGLT2 inhibitor
PK:
t½ 12 hours | Clearance: mixed
Max Dose: 25 day
Max Dose: 25 day
moderate
AE: Genital mycotic infections, polyuria, volume depletion, rare euglycemic DKA
AE: Genital mycotic infections, polyuria, volume depletion, rare euglycemic DKA
Enalapril
Brand: Vasotec (US/EU) / Enam (IN) / Enapril (BD)
Class: Antihypertensive
Subclass: ACE inhibitor (prodrug)
PK:
t½ 11 hours | Clearance: mixed
Max Dose: 40 day
Max Dose: 40 day
moderate
AE: Dry cough, hyperkalemia, dizziness, hypotension, rare angioedema
AE: Dry cough, hyperkalemia, dizziness, hypotension, rare angioedema
Encorafenib
Brand: Braftovi (global)
Class: Anticancer
Subclass: BRAF inhibitor (V600E/K)
PK:
t½ 6 hours | Clearance: hepatic
Max Dose: 450 day
Max Dose: 450 day
moderate
AE: QT prolongation, ocular toxicity, hepatotoxicity, fatigue
AE: QT prolongation, ocular toxicity, hepatotoxicity, fatigue
Enoxaparin
Brand: Clexane / Lovenox
Class: Anticoagulant
Subclass: Factor Xa–predominant LMWH
PK:
t½ 4.5 hours | Clearance: renal
Max Dose: not added
Max Dose: not added
moderate
AE: Bleeding, injection-site hematoma, rare HIT (much lower risk than UFH)
AE: Bleeding, injection-site hematoma, rare HIT (much lower risk than UFH)
Entacapone
Brand: Comtan (US/EU) / Entacom (IN) / Enta (BD)
Class: Antiparkinson
Subclass: COMT inhibitor
PK:
t½ 1 hours | Clearance: hepatic
Max Dose: 2000 day
Max Dose: 2000 day
moderate
AE: Diarrhea, orange discoloration of urine, dyskinesias (due to ↑ levodopa effect)
AE: Diarrhea, orange discoloration of urine, dyskinesias (due to ↑ levodopa effect)
Entrectinib
Brand: Rozlytrek (global)
Class: Anticancer
Subclass: NTRK / ROS1 inhibitor
PK:
t½ 20 hours | Clearance: hepatic
Max Dose: 600 day
Max Dose: 600 day
moderate
AE: Edema, dizziness, cognitive changes, weight gain, hepatotoxicity, CHF risk
AE: Edema, dizziness, cognitive changes, weight gain, hepatotoxicity, CHF risk
Ephedrine
Brand: Ephedrine Sulfate (global)
Class: Sympathomimetic
Subclass: Alpha + Beta agonist; indirect NE releaser
PK:
t½ 6 hours | Clearance: renal
Max Dose: 150 day
Max Dose: 150 day
moderate
AE: Tachycardia, insomnia, anxiety, hypertension
AE: Tachycardia, insomnia, anxiety, hypertension
Epirubicin
Brand: Ellence (global)
Class: Anticancer
Subclass: Anthracycline (topoisomerase II inhibitor)
PK:
t½ 30 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
life-threatening
AE: Myelosuppression, cardiotoxicity, mucositis, alopecia
AE: Myelosuppression, cardiotoxicity, mucositis, alopecia
Eptifibatide
Brand: Integrilin (US/EU) / Eptifiban (IN) / Eptif (BD)
Class: Antiplatelet
Subclass: GP IIb/IIIa inhibitor (IV, cyclic peptide)
PK:
t½ 2.5 hours | Clearance: renal
Max Dose: not added
Max Dose: not added
moderate
AE: Bleeding, thrombocytopenia, hypotension, back pain
AE: Bleeding, thrombocytopenia, hypotension, back pain
Erlotinib
Brand: Tarceva (US/EU) / Erlotinib (IN/BD)
Class: Anticancer
Subclass: EGFR Tyrosine Kinase Inhibitor
PK:
t½ 36 hours | Clearance: hepatic
Max Dose: 150 day
Max Dose: 150 day
severe
AE: Rash, diarrhoea, hepatotoxicity, interstitial lung disease (rare)
AE: Rash, diarrhoea, hepatotoxicity, interstitial lung disease (rare)
Ertugliflozin
Brand: Steglatro (US/EU)
Class: Antidiabetic
Subclass: SGLT2 inhibitor
PK:
t½ 17 hours | Clearance: mixed
Max Dose: 15 day
Max Dose: 15 day
moderate
AE: Genital infections, polyuria, dehydration, euglycemic DKA (rare)
AE: Genital infections, polyuria, dehydration, euglycemic DKA (rare)
Erythromycin
Brand: Erycin (US/EU) / Erythrocin (IN/BD)
Class: Antibiotic
Subclass: Macrolide
PK:
t½ 1.5 hours | Clearance: hepatic
Max Dose: 2000 day
Max Dose: 2000 day
severe
AE: Severe GI upset, QT prolongation, hepatotoxicity
AE: Severe GI upset, QT prolongation, hepatotoxicity
Escitalopram
Brand: Lexapro (US/EU) / Nexito (IN) / Espram (BD)
Class: Antidepressant
Subclass: SSRI (Selective serotonin reuptake inhibitor)
PK:
t½ 27 hours | Clearance: hepatic
Max Dose: 20 day
Max Dose: 20 day
moderate
AE: Insomnia, nausea, headache, sexual dysfunction
AE: Insomnia, nausea, headache, sexual dysfunction
Eszopiclone
Brand: Lunesta (US) / Eszopira (IN) / Zpix (BD)
Class: Sedative/Hypnotic
Subclass: Non-benzodiazepine Z-drug (GABA-A modulator)
PK:
t½ 6 hours | Clearance: hepatic
Max Dose: 3 day
Max Dose: 3 day
moderate
AE: Dysgeusia (metallic/bitter taste), dizziness, next-day impairment, dry mouth
AE: Dysgeusia (metallic/bitter taste), dizziness, next-day impairment, dry mouth
Etanercept
Brand: Enbrel / Intacept
Class: Immunomodulator
Subclass: TNF-alpha inhibitor (receptor-Fc fusion protein)
PK:
t½ 4 days | Clearance: reticuloendothelial
Max Dose: not added
Max Dose: not added
severe
AE: Injection-site reactions, serious infections (TB, fungal), reactivation of HBV, demyelinating disease, neutropenia
AE: Injection-site reactions, serious infections (TB, fungal), reactivation of HBV, demyelinating disease, neutropenia
Ethambutol
Brand: Myambutol (US/EU) / Combutol (IN) / Ethambut (BD)
Class: Antibiotic
Subclass: Anti-TB (cell wall arabinosyl transferase inhibitor)
PK:
t½ 4 hours | Clearance: renal
Max Dose: 1200 day
Max Dose: 1200 day
severe
AE: Optic neuritis (↓visual acuity, red-green dyschromatopsia), rash
AE: Optic neuritis (↓visual acuity, red-green dyschromatopsia), rash
Ethionamide
Brand: Trecator (global) / Ethide (IN/BD)
Class: Antibiotic
Subclass: Anti-TB (isonicotinic acid thioamide)
PK:
t½ 2 hours | Clearance: hepatic
Max Dose: 750 day
Max Dose: 750 day
moderate
AE: Nausea, metallic taste, hepatotoxicity, hypothyroidism
AE: Nausea, metallic taste, hepatotoxicity, hypothyroidism
Ethosuximide
Brand: Zarontin (US/EU) / Emeside (UK) / Ethosuximide (IN/BD)
Class: Anticonvulsant
Subclass: T-type calcium channel blocker
PK:
t½ 60 hours | Clearance: hepatic
Max Dose: 1500 day
Max Dose: 1500 day
moderate
AE: GI upset, nausea, lethargy, headache; rare blood dyscrasias, SJS
AE: GI upset, nausea, lethargy, headache; rare blood dyscrasias, SJS
Etoricoxib
Brand: Etorix / Nucoxia / Tauxib (IN/BD generics)
Class: NSAID
Subclass: Selective COX-2 inhibitor
PK:
t½ 22 hours | Clearance: hepatic
Max Dose: 120 day
Max Dose: 120 day
severe
AE: Dyspepsia, abdominal pain, edema, hypertension, headache, dizziness; increased risk of thrombotic cardiovascular events and, less than non-selective NSAIDs, but still possible…
AE: Dyspepsia, abdominal pain, edema, hypertension, headache, dizziness; increased risk of thrombotic cardiovascular events and, less than non-selective NSAIDs, but still possible…
Exemestane
Brand: Aromasin (global)
Class: Endocrine
Subclass: Aromatase inhibitor (steroidal)
PK:
t½ 27 hours | Clearance: hepatic
Max Dose: 25 day
Max Dose: 25 day
moderate
AE: Hot flashes, arthralgia, fatigue, bone loss
AE: Hot flashes, arthralgia, fatigue, bone loss
Exenatide
Brand: Byetta (BID) / Bydureon (weekly ER)
Class: Antidiabetic
Subclass: GLP-1 receptor agonist
PK:
t½ 2.4 hours | Clearance: renal
Max Dose: 20 day
Max Dose: 20 day
moderate
AE: Nausea, vomiting, diarrhea, headache; injection-site reactions (ER)
AE: Nausea, vomiting, diarrhea, headache; injection-site reactions (ER)