All Drugs
Showing 33 drugs
starting with: P
Paclitaxel
Brand: Taxol (global) / Paclitax (IN/BD)
Class: Anticancer
Subclass: Taxane (microtubule stabilizer)
PK:
t½ 20 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
severe
AE: Neutropenia, peripheral neuropathy, hypersensitivity reactions, alopecia
AE: Neutropenia, peripheral neuropathy, hypersensitivity reactions, alopecia
Palbociclib
Brand: Ibrance (US/EU) / Palbociclib (IN/BD)
Class: Anticancer
Subclass: CDK4/6 inhibitor
PK:
t½ 29 hours | Clearance: hepatic
Max Dose: 125 day
Max Dose: 125 day
severe
AE: Neutropenia, infections, stomatitis, fatigue
AE: Neutropenia, infections, stomatitis, fatigue
Paliperidone
Brand: Invega (US/EU) / Palidon (IN) / Invega Sustenna (LAI)
Class: Psychiatric
Subclass: Atypical antipsychotic (D2/5HT2A blocker)
PK:
t½ 23 hours | Clearance: renal
Max Dose: 12 day
Max Dose: 12 day
moderate
AE: Extrapyramidal symptoms, hyperprolactinemia, weight gain, akathisia
AE: Extrapyramidal symptoms, hyperprolactinemia, weight gain, akathisia
Paracetamol + Tramadol
Brand: Ultracet / Tramapar / Tramacet
Class: Analgesic Combination
Subclass: Opioid + Non-opioid analgesic (FDC)
PK:
t½ 6 hours | Clearance: mixed
Max Dose: 8 day
Max Dose: 8 day
moderate
AE: Drowsiness, dizziness, nausea, constipation; hepatotoxicity at high doses; serotonin syndrome risk; respiratory depression at high doses
AE: Drowsiness, dizziness, nausea, constipation; hepatotoxicity at high doses; serotonin syndrome risk; respiratory depression at high doses
Paromomycin
Brand: Humatin / Paromomycin (generic)
Class: Antiparasitic
Subclass: Aminoglycoside antiprotozoal (non-absorbed)
PK:
t½ 6 hours | Clearance: mixed
Max Dose: not added
Max Dose: not added
mild
AE: GI upset, cramps; systemic toxicity rare
AE: GI upset, cramps; systemic toxicity rare
Paroxetine
Brand: Paxil (US/EU) / Paro-20 (IN) / Paxtin (BD)
Class: Antidepressant
Subclass: SSRI (Selective serotonin reuptake inhibitor)
PK:
t½ 21 hours | Clearance: hepatic
Max Dose: 50 day
Max Dose: 50 day
moderate
AE: Dry mouth, constipation, weight gain, sexual dysfunction, withdrawal symptoms on abrupt cessation
AE: Dry mouth, constipation, weight gain, sexual dysfunction, withdrawal symptoms on abrupt cessation
Pembrolizumab
Brand: Keytruda (global)
Class: Anticancer
Subclass: PD-1 Immune Checkpoint Inhibitor
PK:
t½ 528 hours | Clearance: hepatic
Max Dose: 200 day
Max Dose: 200 day
life-threatening
AE: Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies, thyroid dysfunction
AE: Immune-mediated pneumonitis, colitis, hepatitis, endocrinopathies, thyroid dysfunction
Pemetrexed
Brand: Alimta (global)
Class: Anticancer
Subclass: Antimetabolite (multitargeted antifolate)
PK:
t½ 3.5 hours | Clearance: renal
Max Dose: not added
Max Dose: not added
moderate
AE: Myelosuppression, fatigue, rash, mucositis
AE: Myelosuppression, fatigue, rash, mucositis
Perampanel
Brand: Fycompa (US/EU) / Perampanel (IN/BD)
Class: Anticonvulsant
Subclass: AMPA receptor antagonist
PK:
t½ 105 hours | Clearance: hepatic
Max Dose: 12 day
Max Dose: 12 day
moderate
AE: Dizziness, somnolence, ataxia, irritability, aggression, falls
AE: Dizziness, somnolence, ataxia, irritability, aggression, falls
Perindopril
Brand: Coversyl (US/EU) / Perigard (IN) / Perilace (BD)
Class: Antihypertensive
Subclass: ACE inhibitor (prodrug, long-acting)
PK:
t½ 30 hours | Clearance: mixed
Max Dose: 8 day
Max Dose: 8 day
moderate
AE: Cough, hyperkalemia, dizziness, rare angioedema
AE: Cough, hyperkalemia, dizziness, rare angioedema
Perindopril + Indapamide
Brand: Coversyl Plus
Class: Antihypertensive
Subclass: ACE Inhibitor + Thiazide-like diuretic
PK:
t½ 12 hours | Clearance: mixed
Max Dose: not added
Max Dose: not added
moderate
AE: Dry cough, hypotension, hyponatremia
AE: Dry cough, hypotension, hyponatremia
Pertuzumab
Brand: Perjeta (global) / Pertuzumab (IN/BD)
Class: Anticancer
Subclass: HER2 monoclonal antibody
PK:
t½ 432 hours | Clearance: hepatic
Max Dose: 420 day
Max Dose: 420 day
severe
AE: Diarrhoea, rash, neutropenia, infusion reactions; potential cardiotoxicity (esp. with trastuzumab); embryo-fetal toxicity
AE: Diarrhoea, rash, neutropenia, infusion reactions; potential cardiotoxicity (esp. with trastuzumab); embryo-fetal toxicity
Phenytoin
Brand: Dilantin (US) / Eptoin (IN) / Dantoin (BD)
Class: Anticonvulsant
Subclass: Sodium channel blocker
PK:
t½ 22 hours | Clearance: hepatic
Max Dose: 500 day
Max Dose: 500 day
severe
AE: Ataxia, nystagmus, gingival hyperplasia, hirsutism, rash, neuropathy
AE: Ataxia, nystagmus, gingival hyperplasia, hirsutism, rash, neuropathy
Phosphate: Sodium phosphate
Class: Minerals
Subclass: Electrolyte supplement
PK:
t½ not added | Clearance: not added
Max Dose: not added
Max Dose: not added
Pioglitazone
Brand: Actos (US/EU) / Pioz (IN) / Piobet (BD)
Class: Antidiabetic
Subclass: Thiazolidinedione (PPAR-γ agonist)
PK:
t½ 7 hours | Clearance: hepatic
Max Dose: 45 day
Max Dose: 45 day
moderate
AE: Weight gain, edema, fractures in women, rare bladder cancer risk
AE: Weight gain, edema, fractures in women, rare bladder cancer risk
Piperacillin + Tazobactam
Brand: Zosyn (US/EU) / Pipzo (IN) / Piptaz (BD)
Class: Antibiotic
Subclass: Extended-spectrum penicillin + β-lactamase inhibitor
PK:
t½ 1 hours | Clearance: renal
Max Dose: 18000 day
Max Dose: 18000 day
severe
AE: Diarrhea, rash, thrombocytopenia, electrolyte imbalance (hypokalemia)
AE: Diarrhea, rash, thrombocytopenia, electrolyte imbalance (hypokalemia)
Piracetam
Brand: Nootropil (EU) / Piracetam (IN) / Lucetam (BD)
Class: Neurological
Subclass: Nootropic (GABA analog, neuronal membrane modulator)
PK:
t½ 5 hours | Clearance: renal
Max Dose: 4800 day
Max Dose: 4800 day
mild
AE: Nervousness, insomnia, agitation, weight gain, GI upset
AE: Nervousness, insomnia, agitation, weight gain, GI upset
Piroxicam
Brand: Feldene (global) / Pirox, Roxicam (IN/BD)
Class: NSAID
Subclass: Oxicam derivative
PK:
t½ 50 hours | Clearance: hepatic
Max Dose: 20 day
Max Dose: 20 day
severe
AE: Severe gastric ulceration, GI bleed, edema, renal worsening, rash (including SJS/TEN)
AE: Severe gastric ulceration, GI bleed, edema, renal worsening, rash (including SJS/TEN)
Pitavastatin
Brand: Livalo (US/EU) / Pivasta (IN) / Pitava (JP)
Class: Cardiovascular
Subclass: Statin (HMG-CoA reductase inhibitor)
PK:
t½ 12 hours | Clearance: hepatic
Max Dose: 4 day
Max Dose: 4 day
mild
AE: Myalgia, mild liver enzyme elevation
AE: Myalgia, mild liver enzyme elevation
Pomalidomide
Brand: Pomalyst (global)
Class: Anticancer
Subclass: Immunomodulatory agent (IMiD)
PK:
t½ 7.5 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
severe
AE: Myelosuppression, fatigue, thrombosis risk, rash
AE: Myelosuppression, fatigue, thrombosis risk, rash
Potassium: Potassium chloride
Class: Minerals
Subclass: Electrolyte supplement
PK:
t½ not added | Clearance: not added
Max Dose: not added
Max Dose: not added
Pralsetinib
Brand: Gavreto (global)
Class: Anticancer
Subclass: RET inhibitor
PK:
t½ 22 hours | Clearance: hepatic
Max Dose: 400 day
Max Dose: 400 day
severe
AE: Interstitial lung disease/pneumonitis, hypertension, hepatotoxicity, neutropenia
AE: Interstitial lung disease/pneumonitis, hypertension, hepatotoxicity, neutropenia
Pramipexole
Brand: Mirapex (US/EU) / Pramirol (IN) / Pexola (BD)
Class: Antiparkinson
Subclass: Dopamine agonist (D2/D3)
PK:
t½ 10 hours | Clearance: renal
Max Dose: 4.5 day
Max Dose: 4.5 day
moderate
AE: Nausea, orthostatic hypotension, hallucinations, impulse control disorders (gambling, hypersexuality)
AE: Nausea, orthostatic hypotension, hallucinations, impulse control disorders (gambling, hypersexuality)
Prasugrel
Brand: Effient (US/EU) / Prasita (IN) / Prasurel (IN) / Prasugrel (BD)
Class: Antiplatelet
Subclass: P2Y12 inhibitor (irreversible, prodrug)
PK:
t½ 7 hours | Clearance: hepatic
Max Dose: 10 day
Max Dose: 10 day
severe
AE: Bleeding (higher risk than clopidogrel), easy bruising, anemia
AE: Bleeding (higher risk than clopidogrel), easy bruising, anemia
Pravastatin
Brand: Pravachol (US/EU) / Pravator (IN) / Vastatin (BD)
Class: Cardiovascular
Subclass: Statin (HMG-CoA reductase inhibitor)
PK:
t½ 1.8 hours | Clearance: hepatic
Max Dose: 80 day
Max Dose: 80 day
mild
AE: Mild transaminitis, headache, mild GI upset
AE: Mild transaminitis, headache, mild GI upset
Praziquantel
Brand: Biltricide / Prazitel
Class: Antiparasitic
Subclass: Anthelmintic (schistosomicide)
PK:
t½ 1.5 hours | Clearance: hepatic
Max Dose: 3600 day
Max Dose: 3600 day
moderate
AE: Dizziness, headache, abdominal pain; transient fever due to worm death; urticaria rarely
AE: Dizziness, headache, abdominal pain; transient fever due to worm death; urticaria rarely
Prazosin
Brand: Minipress (US/EU) / Prazopress (IN) / Prazo (BD)
Class: Antihypertensive
Subclass: Selective α₁-adrenergic blocker
PK:
t½ 3 hours | Clearance: hepatic
Max Dose: 20 day
Max Dose: 20 day
moderate
AE: Postural hypotension, dizziness, headache, palpitations, nasal congestion
AE: Postural hypotension, dizziness, headache, palpitations, nasal congestion
Prednisolone
Brand: Pred
Class: Corticosteroid
Subclass: Glucocorticoid
PK:
t½ 3 hours | Clearance: hepatic
Max Dose: 60 day
Max Dose: 60 day
moderate
AE: Weight gain, mood changes, immunosuppression
AE: Weight gain, mood changes, immunosuppression
Pregabalin
Brand: Lyrica (US/EU) / Pregaba (IN/BD)
Class: Neurological
Subclass: Neuropathic pain / Central sensitization
PK:
t½ 6 hours | Clearance: renal
Max Dose: 600 day
Max Dose: 600 day
moderate
AE: Dizziness, sedation, euphoria, edema, weight gain
AE: Dizziness, sedation, euphoria, edema, weight gain
Primaquine
Brand: Primaquine phosphate
Class: Antimalarial
Subclass: 8-aminoquinoline
PK:
t½ 7 hours | Clearance: hepatic
Max Dose: 30 day
Max Dose: 30 day
severe
AE: GI upset, methemoglobinemia, dose-related hemolytic anemia (especially in G6PD deficiency).
AE: GI upset, methemoglobinemia, dose-related hemolytic anemia (especially in G6PD deficiency).
Propranolol
Brand: Inderal (US/EU) / Ciplar (IN) / Propranolol (BD)
Class: Antihypertensive
Subclass: Non-selective beta blocker
PK:
t½ 4 hours | Clearance: hepatic
Max Dose: 320 day
Max Dose: 320 day
severe
AE: Fatigue, bradycardia, bronchospasm, sleep disturbance, vivid dreams
AE: Fatigue, bradycardia, bronchospasm, sleep disturbance, vivid dreams
Pyrantel Pamoate
Brand: Pin-X / Pyrantel (IN-BD generic)
Class: Antiparasitic
Subclass: Depolarizing neuromuscular blocker (Helminths)
PK:
t½ 5 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
mild
AE: Nausea, abdominal cramps, diarrhea, dizziness, headache. Rare: elevated LFTs.
AE: Nausea, abdominal cramps, diarrhea, dizziness, headache. Rare: elevated LFTs.
Pyrazinamide
Brand: PZA (global) / Zinamide (IN) / Pyrazide (BD)
Class: Antibiotic
Subclass: Anti-TB (nicotinamide analog)
PK:
t½ 9.5 hours | Clearance: hepatic
Max Dose: 2000 day
Max Dose: 2000 day
severe
AE: Hepatotoxicity, hyperuricemia → gout flares, GI upset
AE: Hepatotoxicity, hyperuricemia → gout flares, GI upset