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Showing 20 drugs starting with: I

Ibuprofen

Brand: Advil / Brufen / Motrin
Class: NSAID
Subclass: Analgesic / Antipyretic /Propionic acid derivative
PK: t½ 2 hours | Clearance: hepatic
Max Dose: 2400 day
severe
AE: Gastric irritation, dyspepsia, nausea, fluid retention, renal function decline (dose-dependent), **RARE: severe cutaneous reactions including Stevens-Johnson Syndrome (SJS)/TEN**

Idarubicin

Brand: Idamycin (global)
Class: Anticancer
Subclass: Anthracycline (topoisomerase II inhibitor)
PK: t½ 22 hours | Clearance: hepatic
Max Dose: not added
life-threatening
AE: Cardiotoxicity, myelosuppression, nausea/vomiting, mucositis

Imatinib

Brand: Gleevec (US/EU) / Imatinib (IN/BD)
Class: Anticancer
Subclass: BCR-ABL Tyrosine Kinase Inhibitor
PK: t½ 18 hours | Clearance: hepatic
Max Dose: 800 day
moderate
AE: Fluid retention, edema, N/V, rash, cytopenias

Imipramine

Brand: Tofranil (US/EU) / Depsonil (IN) / Imipra (BD)
Class: Antidepressant
Subclass: TCA (Tricyclic antidepressant)
PK: t½ 20 hours | Clearance: hepatic
Max Dose: 200 day
severe
AE: Anticholinergic effects, sedation, orthostatic hypotension, arrhythmias

Indapamide

Brand: Natrilix / Lozol
Class: Diuretic
Subclass: Thiazide-like diuretic
PK: t½ 16 hours | Clearance: hepatic
Max Dose: 2.5 day
moderate
AE: Hyponatremia, hypokalemia, dizziness

Indomethacin

Brand: Indocap, Indomet (IN/BD), Indocin (global)
Class: NSAID
Subclass: Indole acetic acid derivative
PK: t½ 4.5 hours | Clearance: hepatic
Max Dose: 200 day
moderate
AE: Severe gastric irritation, headache, dizziness, CNS effects, renal impairment, edema, hypertension

Infliximab

Brand: Remicade / Inflectra
Class: Immunomodulator
Subclass: TNF-alpha inhibitor (chimeric mAb)
PK: t½ 9.5 days | Clearance: reticuloendothelial
Max Dose: not added
severe
AE: Infusion reactions, severe infections (TB, fungal), hepatotoxicity, reactivation of hepatitis B, demyelination, heart failure exacerbation

Insulin Degludec

Brand: Tresiba (US/EU)
Class: Antidiabetic
Subclass: Ultra-long basal insulin
PK: t½ 25 hours | Clearance: other
Max Dose: not added
severe
AE: Hypoglycemia, weight gain, injection-site reactions

Insulin Detemir U100

Brand: Levemir (US/EU)
Class: Antidiabetic
Subclass: Basal insulin (long-acting)
PK: t½ 12 hours | Clearance: other
Max Dose: not added
severe
AE: Hypoglycemia, weight gain, injection-site reactions

Insulin Glargine U100

Brand: Lantus (US/EU) / Basalog (IN) / Basugine (BD)
Class: Antidiabetic
Subclass: Basal insulin (long-acting)
PK: t½ 12 hours | Clearance: other
Max Dose: not added
severe
AE: Hypoglycemia, weight gain, lipodystrophy at injection site

Ipilimumab

Brand: Yervoy (global) / Ipilimumab (IN/BD)
Class: Anticancer
Subclass: CTLA-4 Immune Checkpoint Inhibitor
PK: t½ 360 hours | Clearance: other
Max Dose: 3 day
life-threatening
AE: Severe immune-mediated colitis, hepatitis, dermatitis, endocrine failure

Iron: Ferrous fumarate

Class: Minerals
Subclass: Iron supplement
PK: t½ not added | Clearance: not added
Max Dose: not added

Iron: Ferrous gluconate

Class: Minerals
Subclass: Iron supplement
PK: t½ not added | Clearance: not added
Max Dose: not added

Iron: Ferrous sulfate

Class: Minerals
Subclass: Iron supplement
PK: t½ not added | Clearance: not added
Max Dose: not added

Isoniazid

Brand: INH (global) / Isonex (IN/BD)
Class: Antibiotic
Subclass: Anti-TB (Hydrazide)
PK: t½ 3 hours | Clearance: hepatic
Max Dose: 300 day
severe
AE: Peripheral neuropathy, hepatotoxicity

Isoprenaline

Brand: Isuprel
Class: Sympathomimetic
Subclass: Non-selective β-agonist
PK: t½ 0.05 hours | Clearance: hepatic
Max Dose: not added
severe
AE: Tachycardia, palpitations, arrhythmias, flushing, tremor, headache, hypotension

Isosorbide Dinitrate

Brand: Isordil (US/EU) / Sorbitrate (IN) / Isodinit (BD)
Class: Antianginal
Subclass: Organic nitrate vasodilator
PK: t½ 1 hours | Clearance: hepatic
Max Dose: 120 day
moderate
AE: Headache, hypotension, flushing, syncope, reflex tachycardia

Isosorbide Mononitrate

Brand: Monoket (US/EU) / Imdur (US/EU) / Monotrate (IN) / Isomack (BD)
Class: Antianginal
Subclass: Organic nitrate vasodilator
PK: t½ 5 hours | Clearance: hepatic
Max Dose: 120 day
moderate
AE: Headache, hypotension, dizziness, flushing, syncope

Ivermectin

Brand: Stromectol / Ivermectin (generic)
Class: Antiparasitic
Subclass: Macrocyclic lactone (Avermectin)
PK: t½ 18 hours | Clearance: hepatic
Max Dose: not added
moderate
AE: Dizziness; pruritus; rash; lymphadenitis; Mazzotti reaction in onchocerciasis

Ixekizumab

Brand: Taltz
Class: Immunomodulator
Subclass: IL-17A monoclonal antibody
PK: t½ 13 days | Clearance: reticuloendothelial
Max Dose: not added
moderate
AE: Injection site reactions, infections (URTI, candidiasis), neutropenia, inflammatory bowel disease flare