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Showing 19 drugs starting with: L

Labetalol

Brand: Trandate (US/EU) / Labeta (IN) / Labocard (BD)
Class: Antihypertensive
Subclass: Combined α₁ + β blocker
PK: t½ 6 hours | Clearance: hepatic
Max Dose: 1200 day
moderate
AE: Postural hypotension (esp. after IV), fatigue, bradycardia, nasal congestion, scalp tingling

Lamotrigine

Brand: Lamictal (US/EU) / Lamitor (IN) / Lamotrin (BD)
Class: Anticonvulsant
Subclass: Sodium channel blocker / glutamate release inhibitor
PK: t½ 29 hours | Clearance: hepatic
Max Dose: 200 day
severe
AE: Rash (can progress to SJS/TEN), dizziness, diplopia, headache

Lapatinib

Brand: Tykerb (global)
Class: Anticancer
Subclass: HER2 / EGFR dual TKI
PK: t½ 14 hours | Clearance: hepatic
Max Dose: 1250 day
moderate
AE: Diarrhoea, hepatotoxicity, rash, cardiotoxicity

Larotrectinib

Brand: Vitrakvi (global)
Class: Anticancer
Subclass: NTRK selective inhibitor
PK: t½ 3 hours | Clearance: hepatic
Max Dose: 200 day
moderate
AE: Dizziness, fatigue, nausea, hepatotoxicity

Lenalidomide

Brand: Revlimid (global)
Class: Anticancer
Subclass: Immunomodulatory agent (IMiD)
PK: t½ 3 hours | Clearance: renal
Max Dose: not added
severe
AE: Myelosuppression, thrombosis, fatigue, rash

Letrozole

Brand: Femara
Class: Endocrine
Subclass: Aromatase Inhibitor
PK: t½ 2 days | Clearance: hepatic
Max Dose: 7.5 day
moderate
AE: Hot flashes, headache, arthralgia, fatigue

Levetiracetam

Brand: Keppra (US/EU) / Levipil (IN) / Levepsy (BD)
Class: Anticonvulsant
Subclass: SV2A modulator
PK: t½ 7 hours | Clearance: renal
Max Dose: 3000 day
moderate
AE: Somnolence, fatigue, behavioral irritability, mood changes

Levofloxacin

Brand: Levaquin (US/EU) / Levoday (IN) / Levox (BD)
Class: Antibiotic
Subclass: Fluoroquinolone (respiratory)
PK: t½ 7 hours | Clearance: renal
Max Dose: 750 day
severe
AE: Tendonitis, QT prolongation, dysglycemia, CNS effects

Linagliptin

Brand: Tradjenta (US/EU) / Trajenta (IN) / Linapta (BD)
Class: Antidiabetic
Subclass: DPP-4 inhibitor
PK: t½ 12 hours | Clearance: hepatic
Max Dose: 5 day
mild
AE: Nasopharyngitis, cough, rare pancreatitis, joint pain

Linezolid

Brand: Zyvox (global) / Linox (IN/BD)
Class: Antibiotic
Subclass: Oxazolidinone (MDR-TB + MRSA/VRE)
PK: t½ 5 hours | Clearance: mixed
Max Dose: 600 day
severe
AE: Bone marrow suppression, thrombocytopenia, peripheral neuropathy, optic neuropathy, serotonin syndrome

Liraglutide

Brand: Victoza (T2DM) / Saxenda (Weight loss)
Class: Antidiabetic
Subclass: GLP-1 receptor agonist
PK: t½ 13 hours | Clearance: other
Max Dose: 1.8 day
moderate
AE: Nausea, vomiting, diarrhea/constipation, decreased appetite, injection-site reactions

Lisinopril

Brand: Zestril (US/EU) / Lisoril (IN) / Lisonorm (BD)
Class: Antihypertensive
Subclass: ACE inhibitor (not a prodrug)
PK: t½ 12 hours | Clearance: renal
Max Dose: 40 day
moderate
AE: Dry cough, hyperkalemia, dizziness, hypotension, rare angioedema

Lisinopril + Hydrochlorothiazide

Brand: Zestoretic
Class: Antihypertensive
Subclass: ACEI + Thiazide diuretic
PK: t½ 12 hours | Clearance: renal
Max Dose: not added
moderate
AE: Cough, dizziness, hyperkalemia, hyponatremia

Lixisenatide

Brand: Adlyxin / Lyxumia
Class: Antidiabetic
Subclass: GLP-1 receptor agonist (once-daily)
PK: t½ 3 hours | Clearance: renal
Max Dose: 20 day
moderate
AE: Nausea, vomiting, diarrhea, dizziness, headache

Loperamide

Brand: Imodium (US/EU) / Eldoper (IN) / Loperamide (BD)
Class: Antidiarrheal
Subclass: Peripheral μ-opioid receptor agonist
PK: t½ 11 hours | Clearance: hepatic
Max Dose: 16 day
severe
AE: Constipation, ileus; QT prolongation at overdose

Lorazepam

Brand: Ativan (US/EU) / Lorax (IN) / Loram (BD)
Class: Anxiolytic
Subclass: Benzodiazepine anxiolytic (GABA-A positive allosteric modulator)
PK: t½ 14 hours | Clearance: hepatic
Max Dose: 6 day
moderate
AE: Sedation, confusion, impaired coordination, dependence

Lorlatinib

Brand: Lorbrena (global)
Class: Anticancer
Subclass: ALK inhibitor (3rd gen)
PK: t½ 24 hours | Clearance: hepatic
Max Dose: 100 day
moderate
AE: Cognitive/mood changes, hyperlipidemia, neuropathy, edema, weight gain

Losartan

Brand: Cozaar (US/EU) / Losar (IN) / Losakind (IN) / Lorista (BD)
Class: Antihypertensive
Subclass: Angiotensin II receptor blocker (ARB)
PK: t½ 9 hours | Clearance: hepatic
Max Dose: 100 day
moderate
AE: Dizziness, hyperkalemia (less than ACEIs), renal function changes; rare angioedema

Losartan + Hydrochlorothiazide

Brand: Hyzaar
Class: Antihypertensive
Subclass: ARB + Thiazide diuretic
PK: t½ 6 hours | Clearance: mixed
Max Dose: not added
moderate
AE: Hypotension, dizziness, hyperkalemia, electrolyte imbalance