All Drugs
Showing 15 drugs
starting with: S
Safinamide
Brand: Xadago (global)
Class: Neurological
Subclass: MAO-B inhibitor (reversible, adjunct to levodopa)
PK:
t½ 22 hours | Clearance: hepatic
Max Dose: 100 day
Max Dose: 100 day
moderate
AE: Dyskinesia, insomnia, nausea, hypertension, visual disturbances
AE: Dyskinesia, insomnia, nausea, hypertension, visual disturbances
Salbutamol
Brand: Ventolin / ProAir / Asthalin (IN/BD)
Class: Bronchodilator
Subclass: Short-acting β2 agonist (SABA)
PK:
t½ 5 hours | Clearance: hepatic
Max Dose: 32 day
Max Dose: 32 day
mild
AE: Tremor, palpitations, hypokalemia, tachycardia
AE: Tremor, palpitations, hypokalemia, tachycardia
Secnidazole
Brand: Secnil / Secnidazole (IN/BD generic)
Class: Antiparasitic
Subclass: Nitroimidazole Antiprotozoal
PK:
t½ 20 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
moderate
AE: Nausea, abdominal discomfort, headache, metallic taste; rarely CNS effects.
AE: Nausea, abdominal discomfort, headache, metallic taste; rarely CNS effects.
Secukinumab
Brand: Cosentyx
Class: Immunomodulator
Subclass: IL-17A monoclonal antibody
PK:
t½ 27 days | Clearance: reticuloendothelial
Max Dose: not added
Max Dose: not added
moderate
AE: Infections (URTI common), Candida infections, neutropenia, inflammatory bowel disease flare
AE: Infections (URTI common), Candida infections, neutropenia, inflammatory bowel disease flare
Selegiline
Brand: Eldepryl (US/EU) / Selgin (IN) / Selgine (BD)
Class: Antiparkinson
Subclass: MAO-B inhibitor
PK:
t½ 10 hours | Clearance: hepatic
Max Dose: 10 day
Max Dose: 10 day
moderate
AE: Insomnia, jitteriness, nausea, hypertension if combined with tyramine-rich foods
AE: Insomnia, jitteriness, nausea, hypertension if combined with tyramine-rich foods
Selpercatinib
Brand: Retevmo (global)
Class: Anticancer
Subclass: RET inhibitor
PK:
t½ 32 hours | Clearance: hepatic
Max Dose: 320 day
Max Dose: 320 day
moderate
AE: Hypertension, hepatotoxicity, QT prolongation, dry mouth, edema
AE: Hypertension, hepatotoxicity, QT prolongation, dry mouth, edema
Selumetinib
Brand: Koselugo (global)
Class: Oncology – Targeted therapy
Subclass: MEK inhibitor
PK:
t½ 7 hours | Clearance: hepatic
Max Dose: not added
Max Dose: not added
moderate
AE: Diarrhea, acneiform rash, fatigue, cardiomyopathy risk (↓LVEF)
AE: Diarrhea, acneiform rash, fatigue, cardiomyopathy risk (↓LVEF)
Semaglutide
Brand: Ozempic (US/EU) / Rybelsus (oral) / Semaglu (IN/BD)
Class: Antidiabetic
Subclass: GLP-1 receptor agonist (incretin mimetic)
PK:
t½ 160 hours | Clearance: other
Max Dose: 2 week
Max Dose: 2 week
moderate
AE: Nausea, vomiting, diarrhea, risk of gallbladder disease; rare pancreatitis
AE: Nausea, vomiting, diarrhea, risk of gallbladder disease; rare pancreatitis
Sertraline
Brand: Zoloft (US/EU) / Serlift (IN) / Sertral (BD)
Class: Antidepressant
Subclass: SSRI (Selective serotonin reuptake inhibitor)
PK:
t½ 26 hours | Clearance: hepatic
Max Dose: 200 day
Max Dose: 200 day
moderate
AE: GI upset, insomnia, sexual dysfunction, headache, agitation
AE: GI upset, insomnia, sexual dysfunction, headache, agitation
Simvastatin
Brand: Zocor (US/EU) / Simvotin (IN) / Simvas (BD)
Class: Cardiovascular
Subclass: Statin (HMG-CoA reductase inhibitor)
PK:
t½ 2 hours | Clearance: hepatic
Max Dose: 40 day
Max Dose: 40 day
moderate
AE: Myopathy, liver enzyme rise, GI discomfort
AE: Myopathy, liver enzyme rise, GI discomfort
Sitagliptin
Brand: Januvia (US/EU) / Istavel (IN) / Sitazid (BD)
Class: Antidiabetic
Subclass: DPP-4 inhibitor
PK:
t½ 12 hours | Clearance: renal
Max Dose: 100 day
Max Dose: 100 day
mild
AE: Nasopharyngitis, headache, rare pancreatitis, joint pain
AE: Nasopharyngitis, headache, rare pancreatitis, joint pain
Sodium Valproate
Brand: Epilim (EU) / Valprol (IN) / Encorate (IN) / Gestalt (BD)
Class: Anticonvulsant
Subclass: GABA agonist / HDAC inhibitor
PK:
t½ 14 hours | Clearance: hepatic
Max Dose: 60 day
Max Dose: 60 day
severe
AE: Hepatotoxicity, pancreatitis, tremor, sedation, weight gain, thrombocytopenia, hair loss
AE: Hepatotoxicity, pancreatitis, tremor, sedation, weight gain, thrombocytopenia, hair loss
Spironolactone
Brand: Aldactone (US/EU) / Sactone (IN) / Spironol (BD)
Class: Antihypertensive
Subclass: Potassium-sparing diuretic (Aldosterone antagonist)
PK:
t½ 1.4 hours | Clearance: hepatic
Max Dose: 400 day
Max Dose: 400 day
moderate
AE: Hyperkalemia, gynecomastia, menstrual irregularities, fatigue, dizziness
AE: Hyperkalemia, gynecomastia, menstrual irregularities, fatigue, dizziness
Streptomycin
Brand: Streptomycin (global) / Streptopen (IN) / Strepto (BD)
Class: Antibiotic
Subclass: Anti-TB (aminoglycoside)
PK:
t½ 2.5 hours | Clearance: renal
Max Dose: 1000 day
Max Dose: 1000 day
severe
AE: Ototoxicity (vestibular > cochlear), nephrotoxicity, neuromuscular blockade
AE: Ototoxicity (vestibular > cochlear), nephrotoxicity, neuromuscular blockade
Sulfasalazine
Brand: Azulfidine (US/EU) / Salazopyrin (EU) / Saaz (IN) / SulfaSalazine (BD)
Class: Gastrointestinal
Subclass: Azo-linked 5-ASA prodrug
PK:
t½ 7 hours | Clearance: mixed
Max Dose: 4000 day
Max Dose: 4000 day
moderate
AE: Nausea, headache, rash, reversible oligospermia; hemolysis in G6PD deficiency
AE: Nausea, headache, rash, reversible oligospermia; hemolysis in G6PD deficiency